HINDGRA is also effective in the rare disease pulmonary arterial hypertension. It relaxes the arterial wall, leading to decreased pulmonary arterial resistance and pressure. This, in turn, reduces the workload of the right ventricle of the heart and improves symptoms of right-sided heart failure. Because PDE-5 is primarily distributed within the arterial wall smooth muscle of the lungs and penis, sildenafil citrate of HINDGRA acts selectively in both these areas without inducing vasodilation in other areas of the body. HINDGRA joins bosentan and prostacyclin-based therapies for this condition.

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